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Mutational Profile from Targeted NGS Predicts Survival in LDCT Screening–Detected Lung Cancers  Carla Verri, MSc, Cristina Borzi, MSc, Todd Holscher,

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Presentation on theme: "Mutational Profile from Targeted NGS Predicts Survival in LDCT Screening–Detected Lung Cancers  Carla Verri, MSc, Cristina Borzi, MSc, Todd Holscher,"— Presentation transcript:

1 Mutational Profile from Targeted NGS Predicts Survival in LDCT Screening–Detected Lung Cancers 
Carla Verri, MSc, Cristina Borzi, MSc, Todd Holscher, ScD, Matteo Dugo, PhD, Andrea Devecchi, MSc, Katherine Drake, PhD, Stefano Sestini, MD, Paola Suatoni, MSc, Elisa Romeo, PhD, Gabriella Sozzi, PhD, Ugo Pastorino, MD, Mattia Boeri, PhD  Journal of Thoracic Oncology  Volume 12, Issue 6, Pages (June 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Mutation plot of 94 low-dose computed tomography screening–detected lung tumors. Co-mutation plot of genes mutated in at least one of the 94 National Cancer Institute samples (upper panel) and clinicopathologic and molecular characteristics of patients (lower panel). Genes are ranked according to the number of mutated samples. Tumor protein p53 gene (TP53) was altered in 44 cases and KRAS in 27, followed by alteration of serine/threonine kinase 11 gene (STK11) and cyclin-dependent kinase inhibitor 2A gene (CDKN2A) (seven tumors each), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha gene (PIK3CA) (six), phosphatase and tensin homolog gene (PTEN) (four), EGFR (one L858R and three exon 19 ELREA deletions), and catenin beta 1 gene (CTNNB1) (four, twice together); APC, WNT signaling pathway regulator gene (APC), BRAF, and NRAS (two each); and 12 other genes that were mutated in one sample each. MET, MNNG HOS Transforming gene; SMAD4, SMAD family member 4 gene; ATM serine/threonine kinase (ATM), gene; FGFR1, fibroblast growth factor receptor 1 gene; FGFR2, fibroblast growth factor receptor 2 gene; MLH1, mutL homolog 1 gene; RET, ret proto-oncogene; ERBB4, erb-b2 receptor tyrosine kinase 4 gene; FBXW7, F-box and WD repeat domain containing 7 gene; RB1, retinoblastoma 1 gene; SMO, smoothened, frizzled class receptor gene; SMARCB1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 gene; MSC, microRNA signature classifier; ADC, adenocarcinoma; SCC, squamous cell carcinoma; neuroendocrine tumor; NA, not available. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Clinicopathologic characteristics associated with mutational status of tumor protein p53 gene (TP53) and KRAS. (A) Box plot reporting the distribution of pack-years index according to TP53 mutational status: p value for two-tailed Mann-Whitney test. (B) Kaplan-Meier curve in strata of KRAS mutational status. Overall survival (OS) and p value for log-rank test are reported. mut, mutation; wt, wild type. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Kaplan-Meier analysis according to mutational status and microRNA signature classifier (MSC). Kaplan-Meier curves in strata of mutational status alone (A), the combination of mutational status and MSC (B), and the combination of mutational status, MSC, and tumor stage (C). MSC risk level: high (H), intermediate (I), and low (L). Overall survival (OS) and p value for log-rank test are reported. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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