1. Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity 
Nathan K. Archer, Migena N. Dilolli, Lloyd S. Miller 
Journal of Investigative Dermatology 
Volume 137, Issue 11, Pages (November 2017)
DOI: /j.jid
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2. Figure 1
Antimicrobial activity of LCE proteins in normal skin and psoriasis. (a) Compared with normal skin (wt/wt), the skin from individuals with the LCE3B/C-del has constitutive expression of LCE3A, which has antimicrobial activity against bacteria in the skin microbiome. (b) In lesional psoriasis skin, wt/wt individuals have markedly increased expression of LCE3A, LCE3B, and LCE3C, whereas individuals with the LCE3B/C-del only have upregulated LCE3A. All have broad-spectrum antimicrobial activity against bacteria in the skin microbiome. Altered self or microbial antigen exposure in the setting of LCE3B/C-del might elicit HLA-C*06:02 restricted immune responses, providing an explanation for the epistatic relationship between these two psoriasis gene susceptibility loci. LCE, late cornified envelope.
Journal of Investigative Dermatology  , DOI: ( /j.jid )
Copyright © 2017 The Authors Terms and Conditions