1. Combination of Two Urinary Biomarkers Predicts Acute Kidney Injury After Adult Cardiac Surgery 
Daisuke Katagiri, MD, Kent Doi, MD, PhD, Kenjiro Honda, MD, Kousuke Negishi, MD, PhD, Toshiro Fujita, MD, PhD, Motoyuki Hisagi, MD, PhD, Minoru Ono, MD, PhD, Takehiro Matsubara, MD, PhD, Naoki Yahagi, MD, PhD, Masao Iwagami, MD, Takayasu Ohtake, MD, PhD, Shuzo Kobayashi, MD, PhD, Takeshi Sugaya, PhD, Eisei Noiri, MD, PhD 
The Annals of Thoracic Surgery 
Volume 93, Issue 2, Pages (February 2012)
DOI: /j.athoracsur
Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-D-glucosaminidase (NAG) in the perioperative period of cardiac surgery. Urinary L-FABP (A) and (C) and NAG (B) and (D) were measured before surgery (pre), at intensive care unit arrival (0 hours), and 4 and 12 hours thereafter. Of 77 enrolled patients, 28 patients were diagnosed as having acute kidney injury (AKI). Box plots show the median (center line), the 25th and 75th percentiles, and the range (whiskers). Results are presented as absolute concentration (A) and (B) and corrected by urinary creatinine (Cre) concentration (C) and (D). (#, p < 0.05.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Change in urinary creatinine concentration. Urinary creatinine was measured using the same sample used for L-type fatty acid-binding protein and N-acetyl-β-D-glucosaminidase measurements. (#, p < 0.05; AKI = acute kidney injury.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

4. Fig 3
Improvement of acute kidney injury (AKI) prediction by adding the panel of urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-D-glucosaminidase measurements. Receiver operating characteristic (ROC) curves for AKI risk prediction by a clinical model (area under the curve-ROC 0.79) and a combined model with the biomarker panel and clinical predictors (black line; AUC-ROC 0.86). Clinical predictors (gray line) included age, gender, complication of diabetes and hypertension, operation time, and serum creatinine measured before surgery.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions