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Immune Reconstitution Kinetics as an Early Predictor for Mortality using Various Hematopoietic Stem Cell Sources in Children Imke Heleen Bartelink, Svetlana V. Belitser, Catherijne A.J. Knibbe, Meindert Danhof, Anne J. de Pagter, Toine C.G. Egberts, Jaap Jan Boelens Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages (February 2013) DOI: /j.bbmt Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 1 Neutrophil engraftment (time to reach at least 500 neutrophils) in the id-Sib, u-BM, and u-CB groups. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 2 Kinetics of the lympohocyte subsets per cell source in the first 90 days. (A) Maximum number of CD19+ cells. (B) Area under the CD19+ cell-time curve (AUC0-90). (C) Maximum number of CD4+ cells. (D) Number of CD4+ cells at day 90 (as a cross-sectional marker). (E) CD4+ AUC0-90. (F) Occurrence of a peak in CD4+ cell counts within this time period. (G) Maximum cell number of CD8+ cells. (H) CD8+ AUC0-90. (I) Occurrence of a peak in CD8+ cell counts within this time period. (J) Ratio of CD4+ naïve to memory cells. (K) Ratio of CD8+ naïve to memory cells. (L) Ratio of CD4+ to CD8+ cells. (M) Maximum number of NK cells. The white box represents the 25th to the 75th percentile of the data. Dots represent extreme values. The triangle represents median value. The gray box approximates the 95% CIs of the median value. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 3 Overall survival in the id-Sib, u-BM, and u-CB groups.
Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 4 (A-C) Kaplan-Meier curve of CD4+ AUC0–90 using the cutoff value in relation to survival in the id-Sib (A), u-BM (B), and u-CB (C) groups. (D) CD4+ AUC0–90 combined with a peak in CD4+ cell count during the first 90 days post-HSCT for the 3 groups combined. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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Biology of Blood and Marrow Transplantation 2013 19, 305-313DOI: (10
Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions
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