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A major non-HLA locus in celiac disease maps to chromosome 191

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Presentation on theme: "A major non-HLA locus in celiac disease maps to chromosome 191"— Presentation transcript:

1 A major non-HLA locus in celiac disease maps to chromosome 191
Martine J Van Belzen, Jos W.R Meijer, Lodewijk A Sandkuijl, Alfons F.J Bardoel, Chris J.J Mulder, Peter L Pearson, Roderick H.J Houwen, Cisca Wijmenga  Gastroenterology  Volume 125, Issue 4, Pages (October 2003) DOI: /S (03)

2 Figure 1 Maximum lod scores from the multipoint linkage analysis present on each chromosome in the initial genome-wide screen in 67 families. The horizontal line indicates a nominal significance threshold of All regions reaching this threshold were further investigated in a follow-up study. Gastroenterology  , DOI: ( /S (03) )

3 Figure 2 Distribution of MLS values after fine mapping of the candidate regions on chromosomes 1, 5, 6, 8, 19, and 20 in the initial 67 families (thick line) and in all 82 families (thin line). The triangular symbols denote the positions of the markers on the chromosomes. Chromosome 2 is also included in this Figure because of its possible implication in celiac disease. The CELIAC3 region was only genotyped in the initial 67 families. Gastroenterology  , DOI: ( /S (03) )


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