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Effectiveness and Cost-effectiveness of Measuring Fecal Calprotectin in Diagnosis of Inflammatory Bowel Disease in Adults and Children  Zhuo Yang, Nick.

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Presentation on theme: "Effectiveness and Cost-effectiveness of Measuring Fecal Calprotectin in Diagnosis of Inflammatory Bowel Disease in Adults and Children  Zhuo Yang, Nick."— Presentation transcript:

1 Effectiveness and Cost-effectiveness of Measuring Fecal Calprotectin in Diagnosis of Inflammatory Bowel Disease in Adults and Children  Zhuo Yang, Nick Clark, K.T. Park  Clinical Gastroenterology and Hepatology  Volume 12, Issue 2, Pages e2 (February 2014) DOI: /j.cgh Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 Overview of model structure. (A) Model 1 and (B) Model 2. *Endoscopy = upper endoscopy and colonoscopy with histopathology. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 One-way sensitivity analysis.
Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 PSA. Acceptability curves from the 3000 independent simulations. Panels A and B show FCS strategy decreases in cost-effectiveness at higher WTP. Panels C and D show that FCS at low FC cutoff values have a wider range of WTP (between 2 vertical hurdles) in which FCS at 50 μg/g is more likely cost-effective than FCS at 100 μg/g (between the left hurdle and the origin). Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

5 Figure 4 Three-way sensitivity analysis for using FC assay in pediatric group. ICER of DEE strategy at different pre-test probabilities of true IBD, as compared with FCS strategy. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Three-way sensitivity analysis for using FC assay in adult group: FC sensitivity, specificity, and proportion of true IBDs among suspected adult IBD patients. The 4 charts show the color-coded map of ICER of DEE strategy at different pre-test probabilities of true IBD, as compared with FCS strategy. The hollow squares indicate the base-case sensitivity and specificity of FCS in the adult group. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions


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