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Volume 139, Issue 1, Pages e24 (July 2010)

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1 Volume 139, Issue 1, Pages 130-139.e24 (July 2010)
Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease  Kari E. Roberts, Steven M. Kawut, Michael J. Krowka, Robert S. Brown, James F. Trotter, Vijay Shah, Inga Peter, Hocine Tighiouart, Nandita Mitra, Elizabeth Handorf, James A. Knowles, Steven Zacks, Michael B. Fallon  Gastroenterology  Volume 139, Issue 1, Pages e24 (July 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Classification and regression tree (CART). Each split in the tree maximizes the separation of cases and controls based on SNP genotypes. Gastroenterology  , e24DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Supplementary Figure 1 Linkage disequilibrium structure of Caveolin 3 (CAV3). Pair-wise linkage disequilibrium (LD) between loci (D' and r2) and haplotype structure were measured using Haploview Here, LD was measured using all SNPs genotyped in the controls in this study. The strength of LD is depicted graphically for each pair-wise comparison (squares), such that white and blue represent low levels of LD, and red indicates high levels of LD (see color key). The SNPs are identified by their RS numbers and displayed relative to the candidate gene region. The display range of the chromosome (black line) corresponds to the genomic region of the candidate gene (roughly coding sequence ± 5–10 kilobases) targeted by this study. Exon/intron structure of the genes is indicated by thick/thin purple lines according to genome assembly hg17/May Annotated graphical images were generated using into LocusView Gastroenterology  , e24DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Supplementary Figure 2 Linkage disequilibrium structure of von Willebrands Factor (VWF). Pair-wise linkage disequilibrium (LD) between loci (D' and r2) and haplotype structure were measured using Haploview Here, LD was measured using all SNPs genotyped in the controls in this study. The strength of LD is depicted graphically for each pair-wise comparison (squares), such that white and blue represent low levels of LD, and red indicates high levels of LD (see color key). The SNPs are identified by their RS numbers and displayed relative to the candidate gene region. The display range of the chromosome (black line) corresponds to the genomic region of the candidate gene (roughly coding sequence ± 5–10 kilobases) targeted by this study. Exon/intron structure of the genes is indicated by thick/thin purple lines according to genome assembly hg17/May Annotated graphical images were generated using into LocusView Gastroenterology  , e24DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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