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Reendothelialization of isolated segments of the canine carotid artery with reference to the possible role of the adventitial vasa vasorum  Qun Shi, MD,

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Presentation on theme: "Reendothelialization of isolated segments of the canine carotid artery with reference to the possible role of the adventitial vasa vasorum  Qun Shi, MD,"— Presentation transcript:

1 Reendothelialization of isolated segments of the canine carotid artery with reference to the possible role of the adventitial vasa vasorum  Qun Shi, MD, Hong-De Wu, MD, Lester R. Sauvage, MD, Keith R. Durante, MD, Malay Patel, MD, Arlene R. Wechezak, PhD, Svetlana Kaplan, PhD, Mark Walker  Journal of Vascular Surgery  Volume 12, Issue 4, Pages (October 1990) DOI: / (90)90050-K Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 A Method 1. A 1, Superficial endarterectomy shows inner wall (arrow) removed from everted carotid test segment. A 2, Light microscopy shows removal of approximately 125 μm of the inner wall. A 3, Light microscopy shows the arterial wall that remained after endarterectomy (adventitia is intact). B, Method 2. B 1, Use of balloon catheter for removal of the endothelial lining. B 2, Light microscopy shows the arterial wall of the test segment after balloon denudation. No endothelium remained on the flow surface. The adventitia was left intact. C, Method 3. C 1, Use of balloon catheter for removal of the endothelial lining. C 2, Removal of adventitia (arrow) from the carotid test segment. C 3, a, Light microscopy shows the arterial wall after balloon denudation and removal of adventitia containing vasa vasorum. C 3, b, Light microscopy shows removed adventitia with vasa vasorum present. C 4, Light microscopy shows specimen in which vasa vasorum (arrow) could not be completely removed. (Hematoxylin-eosin stain; original magnification × 40.) Journal of Vascular Surgery  , DOI: ( / (90)90050-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Depiction of sequence of composite graft formation and implanation with placement of protective tubular Gore-Tex shield. Journal of Vascular Surgery  , DOI: ( / (90)90050-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Study of Distribution of vasa vasorum. A, After injection of Microfil into the lumen of the carotid artery, a white network is observed in the adventitia and periarterial tissue. Arrow indicates vagus nerve. B, Rich vasal network filled with Microfil, shown after treatment with methyl salicylate. C, Hematoxylin-cosin stained cross section of carotid wall shows vasa vasorum (arrows) confined to adventitia. (Original magnification × 40.) D, Artist's depiction of dual origin of adventitial vasal network of carotid artery. Arrows indicate luminal estia, which lead to vasal network. Journal of Vascular Surgery  , DOI: ( / (90)90050-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 4-week results. A, Method 1 (superficial endarterectomy with retention of adventitia.) A 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after superficial endarterectomy. A 2, Scanning electron micrograph shows reendothelialization of carotid specimen after superficial endarterectomy. A 3, Positive Factor VIII/von Willebrand factor (FVIII/vWF) effect on flow surface. A 4, Transmitting electron micrograph shows reendothelialization of the flow surface. B, Method 2 (balloon denudation with retention of adventitia). B 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after balloon denudation. B 2, Scanning electron micrograph shows reendothelialization of carotid specimen after balloon denudation. B 3, Positive FVIII/vWF effect on flow surface. B 4, Transmitting electron micrograph shows reendothelialization of the flow surface. C, Method 3 (Balloon denudation with removal of the adventitia). C 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after balloon denudation. C 2, Scanning electron micrograph shows lack of reendothelialization of carotid specimen after balloon denudation and removal of adventitia. C 3, Negative FVIII/vWF effect on flow surface. C 4, Transmitting electron micrograph shows lack of reendothelialization of the flow surface. (Original magnifications: SEM × 1000, FVIII/vWF × 425, TEM × 2500.) Journal of Vascular Surgery  , DOI: ( / (90)90050-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 8-week results. A, Method 1 (superficial endarterectomy with retention of adventitia.) A 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after superficial endarterectomy. A 2, Scanning electron micrograph shows reendothelialization of carotid specimen after superficial endarterectomy. A 3, Positive factor VIII/von Willebrand Factor (FVIII/vWF) effect on flow surface. A 4, Transmitting electron micrograph shows reendothelialization of the flow surface. B, Method 2 (balloon denudation with retention of adventitia). B 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after balloon denudation. B 2, Scanning electron micrograph shows reendothelialization of carotid specimen after balloon denudation. B 3, Positive FVIII/vWF effect on flow surface. B 4, Transmitting electron micrograph shows reendothelialization of the flow surface. C, Method 3 (balloon denudation with removal of the adventitia). C 1, Scanning electron micrograph of control specimen shows absence of endothelium on the flow surface after balloon denudation. C 2, Scanning electron micrograph shows lack of reendothelialization of carotid specimen after balloon denudation. C 3, Negative FVIII/vWF effect on flow surface. C 4, Transmitting electron micrograph shows lack of reendothelialization of the flow surface. (Original magnifications: SEM × 1000, FVIII/vWF × 425, TEM × 2500.) Journal of Vascular Surgery  , DOI: ( / (90)90050-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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