Presentation is loading. Please wait.

Presentation is loading. Please wait.

Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S

Published bySudomo Yuwono Modified over 6 years ago

Similar presentations

Presentation on theme: "Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S"— Presentation transcript:

1 Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆ 
Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S. Fortuno, PhD, Kevin Ho, BSc, Pedro Dimitriu, PhD, William W. Mohn, PhD, David P. Speert, MD, Philip J. Cooper, MBBS, PhD, Monika Esser, MD, Tessa Goetghebuer, MD, Arnaud Marchant, MD, PhD, Tobias R. Kollmann, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 133, Issue 3, Pages e4 (March 2014) DOI: /j.jaci Copyright © 2013 The Authors Terms and Conditions

2 Fig 1 PCA ordination of the innate immune response for all subjects measured by cytokine secretion in response to PRR agonists. A, The variance in cytokine response (12 dimensions) to all ligands. Each color represents a ligand, while each dot represents 1 subject. B, Eigenvectors show the particular correlations of individual cytokines to the ordination of the PCA in A. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

3 Fig 2 Innate immune response to PRR stimulation. PCA ordination of the R848 response is depicted in panel A, LPS in panel B, and PGN in panel C. Each dot represents 1 subject, symbol represents a site, and color represents the stimulation (open [Belgium, Canada, and Ecuador], red [South Africa] for given stimulation). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

4 Fig E1 Cytokine production comparison for all 4 sites per cytokine and stimulation. Box-whisker plots, with the median highlighted for each site (the error bars = 90% CI). A, The production of TH1- and TH17-supporting innate cytokines. B, The production of the proinflammatory cytokines and chemokines, as well as the regulatory cytokine IL-10. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

5 Fig E1 Cytokine production comparison for all 4 sites per cytokine and stimulation. Box-whisker plots, with the median highlighted for each site (the error bars = 90% CI). A, The production of TH1- and TH17-supporting innate cytokines. B, The production of the proinflammatory cytokines and chemokines, as well as the regulatory cytokine IL-10. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

6 Fig E2 Innate immune response to PRR stimulation. PCA ordination of the Poly I:C response is depicted in panel A, PAM in panel B, and MDP in panel C. Each dot represents 1 subject, symbol represents a site, and color represents the stimulation (open [Belgium, Canada, and Ecuador], red [South Africa] for given stimulation). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

7 Fig E3 A simplified vaccine schedule for infants at each site.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 The Authors Terms and Conditions

Download ppt "Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S"

Similar presentations

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge  Grant C. Nicholson, BSc, Harsha H. Kariyawasam,

The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge  Grant C. Nicholson, BSc, Harsha H. Kariyawasam,
Innate microbial sensors and their relevance to allergy

Innate microbial sensors and their relevance to allergy
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial  Eve Hornsby, PhD, Paul E. Pfeffer,

Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial  Eve Hornsby, PhD, Paul E. Pfeffer,
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production  Laura Maggi, PhD, Gianni Montaini, BSc, Alessio Mazzoni,

Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production  Laura Maggi, PhD, Gianni Montaini, BSc, Alessio Mazzoni,
Philip J. Cooper, MB BS, PhD, Martha E. Chico, MD, Leila D

Philip J. Cooper, MB BS, PhD, Martha E. Chico, MD, Leila D
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease  Michael A. Ghebre, MSc, Mona.

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease  Michael A. Ghebre, MSc, Mona.
Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny  Meri K. Tulic, BSc, PhD, Megan Hodder,

Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny  Meri K. Tulic, BSc, PhD, Megan Hodder,
Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease  Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease  Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,
Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions  Shelley F. Stone, PhD, Claire Cotterell,

Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions  Shelley F. Stone, PhD, Claire Cotterell,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD 

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD 
Lu Ban, PhD, Sinéad M. Langan, PhD, Katrina Abuabara, MD, Kim S

Lu Ban, PhD, Sinéad M. Langan, PhD, Katrina Abuabara, MD, Kim S
Immune factors in breast milk related to infant milk allergy are independent of maternal atopy  Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD,

Immune factors in breast milk related to infant milk allergy are independent of maternal atopy  Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD,
Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor–dependent innate antiviral immune responses  Douglas R. McDonald, MD, PhD,

Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor–dependent innate antiviral immune responses  Douglas R. McDonald, MD, PhD,
Kristina Rueter, MD, Anderson P

Kristina Rueter, MD, Anderson P

Similar presentations

Ads by Google