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Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor β3  Jonathan Ghosh, MD, MRCS, Mohammed.

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Presentation on theme: "Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor β3  Jonathan Ghosh, MD, MRCS, Mohammed."— Presentation transcript:

1 Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor β3  Jonathan Ghosh, MD, MRCS, Mohammed Baguneid, Nadeem Khwaja, MRCS, Michael O. Murphy, MRCS, Neill Turner, PhD, Anatassi Halka, MRCS, Mark W. Ferguson, PhD, Cay M. Kielty, PhD, Michael G. Walker, MCh  Journal of Vascular Surgery  Volume 43, Issue 1, Pages (January 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Hematoxylin and eosin–stained sections taken from the same animal. A, Placebo-treated anastomoses. B, After transforming growth factor (TGF)-β3 treatment. *Suture line. Solid arrow represents the combined thickness of the media and intima at the anastomosis; dashed arrow represents the normal surrounding vessel. There was an overall reduction in anastomosis thickness after TGF-β3 compared with placebo, as evidenced by the Intima + Media ratio between the anastomosis and surrounding artery (original magnification, ×4). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Monochrome image of Miller elastin–stained sections, both from the same animal, demonstrating reduced total elastin content after TGF-β3 treatment (A) with decreased numbers of lamellae (arrowhead) compared with placebo (B). *Suture line (original magnification, ×4). IEL, internal elastic lamella; EEL, external elastic lamella. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Total collagen content visualized by refraction of polarized light. A two-fold increase in total collagen content within the vessel wall was seen after surgery with placebo infiltration, in comparison to unoperated artery (A). However, no difference was observed between placebo (B) and TGF-β3 (C) treatment. Arrow highlights suture line (original magnification, ×4). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Collagen type VIII staining is highlighted by the arrow. Reduced type VIII collagen content was seen after treatment with TGF-β3 (A) compared with placebo (B). A control slide is shown in (C) (original magnification, ×4). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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