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Long-term clinical effects of early thymectomy: Associations with autoimmune diseases, cancer, infections, and atopic diseases Judith Gudmundsdottir, MD, PhD, Jonas Söderling, PhD, Håkan Berggren, MD, PhD, Sólveig Óskarsdóttir, MD, PhD, Martin Neovius, PhD, Olof Stephansson, MD, PhD, Olov Ekwall, MD, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 6, Pages e8 (June 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Hazard ratios—thymectomy vs surgery controls (A) and thymectomy vs general population (B). Sex- and age-adjusted hazard ratios with 95% CIs. DM1, Type 1 diabetes mellitus; JIA, juvenile idiopathic arthritis. ∗Only 1 health care visit listing cancer required. †Infections were analyzed as recurrent events using 1 month's grace period. Journal of Allergy and Clinical Immunology , e8DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig E1 Study design overview. Thymectomized individuals and 2 control groups were identified, one surgery control group where individuals had undergone early cardiac surgery not including thymectomy, and an age- and sex-matched 1:10 control group from the general population. Journal of Allergy and Clinical Immunology , e8DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig E2 A, Time trend of cardiac surgery. Number of surgeries per year in children before age 5 years for the thymectomy group (black dots) and the surgery control group (white dots) on left x-axis. The total number of children 5 years or younger in Sweden (gray dots) on right x-axis. B, The extent of thymectomy. The degree of thymectomy as estimated by the surgeon to more than 90%, 75% to 90%, 50% to 75%, and less than 50% in 170 consecutive surgeries during a 2-year period ( ). Results presented separately for less than age 1 year (far left, n = 130) and from age 1 to 5 years (middle, n = 40); and combined results (far right, n = 170). Journal of Allergy and Clinical Immunology , e8DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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