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Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma  Pedram Gerami, MD, Zuxu Yao, PhD, David Polsky, MD, PhD, Burkhard.

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Presentation on theme: "Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma  Pedram Gerami, MD, Zuxu Yao, PhD, David Polsky, MD, PhD, Burkhard."— Presentation transcript:

1 Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma 
Pedram Gerami, MD, Zuxu Yao, PhD, David Polsky, MD, PhD, Burkhard Jansen, MD, Klaus Busam, MD, Jonhan Ho, MD, Mary Martini, MD, Laura K. Ferris, MD, PhD  Journal of the American Academy of Dermatology  Volume 76, Issue 1, Pages e2 (January 2017) DOI: /j.jaad Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

2 Journal of the American Academy of Dermatology 2017 76, 114-120
Journal of the American Academy of Dermatology  , e2DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 1 Noninvasive adhesive patch skin biopsy.
Journal of the American Academy of Dermatology  , e2DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 2 Receiver operating characteristic curves demonstrating the PLA's potential to differentiate primary cutaneous melanoma samples from nonmelanoma samples (primarily atypical nevi) based on LINC00518 and/or preferentially expressed antigen in melanoma detection. AUC, Area under the curve. Journal of the American Academy of Dermatology  , e2DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 3 Comparison of LINC00518 (LINC), actin B (ACTB) and preferentially expressed antigen in melanoma (PRAME) gene expression in patient-derived melanoma xenografts (PDX) compared with nonmelanoma xenografts (A), and in adhesive patch samples of primary cutaneous melanomas processed with the PDX samples as controls (B). Ct, Cycle threshold. Journal of the American Academy of Dermatology  , e2DOI: ( /j.jaad ) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions


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