1. NEDA 2-Year Endpoint: Not a Predictor of Long-Term Stability?

2. Introduction

3. NEDA-3 vs NEDA-4

4. Role of Brain Volume Loss

5. NEDA: CombiRx

6. NEDA in AFFIRM

7. Sustained EDSS in AFFIRM

8. NEDA: Teriflunomide and Fingolimod

9. NEDA: DEFINE and CONFIRM

10. HSR Cohort: 8-Year Follow-Up

11. NEDA and Treatment Strategies

12. Sustained vs Annual NEDA

13. Fingolimod: NEDA-3 vs NEDA-4

14. CLIMB: Observational Cohort

15. CLIMB: Is NEDA a Predictor?

16. NEDA Is Not a Predictor of Stability: MS-EPIC

17. SUMMIT Study

18. Therapeutic Escalation in MS-EPIC

19. MS-EPIC: Predicting Disease Progression

20. MRI Lesions as Predictors of Prognosis

21. Predicting Response to IFNβ

22. Key Messages

23. Key Messages: Levels of NEDA

24. Abbreviations

25. Abbreviations (cont)