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Fig. 3 Pairwise similarity of antimicrobials with respect to metabolic changes induced in M. smegmatis. Pairwise similarity of antimicrobials with respect.

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Presentation on theme: "Fig. 3 Pairwise similarity of antimicrobials with respect to metabolic changes induced in M. smegmatis. Pairwise similarity of antimicrobials with respect."— Presentation transcript:

1 Fig. 3 Pairwise similarity of antimicrobials with respect to metabolic changes induced in M. smegmatis. Pairwise similarity of antimicrobials with respect to metabolic changes induced in M. smegmatis. (A) Similarity heat map for 62 reference antimicrobials. Similarity calculated between each drug-perturbed condition is represented as a symmetric heat map. Diagonal values are not taken into account and are set to not-a-number (gray). Highlighted boxes correspond to the seven main MoAs of the 62 reference compounds. (B) Magnification of panel in (A) showing antimicrobial compounds that blocked gyrase and cell wall synthesis in M. smegmatis. (C) Receiver operating characteristic (ROC) curve measuring the ability of metabolome-based predictions using the iterative hypergeometric test (45) to discriminate antibiotics sharing similar MoAs. Notably, we considered only MoAs that applied to more than one antimicrobial reference compound. CPR, ciprofloxacin; LVX, levofloxacin; MFL, moxifloxacin; NAL, nalidixic acid; NFL, norfloxacin; OFL, ofloxacin; AMX, amoxicillin; AMP, ampicillin; CCL, cefaclor; CTX, ceftriaxone; OCI, oxacillin; BAC, bacitracin; CYC, d-cycloserine; EMB, ethambutol; FOS, fosfomycin; AUC, area under the curve. Mattia Zampieri et al., Sci Transl Med 2018;10:eaal3973 Published by AAAS

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