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A MENage à Trois in Leukemia

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Presentation on theme: "A MENage à Trois in Leukemia"— Presentation transcript:

1 A MENage à Trois in Leukemia
Liya Roudaia, Nancy A. Speck  Cancer Cell  Volume 14, Issue 1, Pages 3-5 (July 2008) DOI: /j.ccr Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Multiple Lines of Evidence Demonstrate that Menin's Role Is to Tether LEDGF to MLL Conditional deletion of menin, knockdown of LEDGF, and mutations that disrupt binding of LEDGF to either MLL or menin all impair the MLL-ENL fusion protein's transforming activity and constitutive expression of the MLL target Hoxa9. Fusion of LEDGF's chromatin-binding PWWP domain to MLL supplants menin activity. Cancer Cell  , 3-5DOI: ( /j.ccr ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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