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Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial Stefano Masi, Marco Orlandi, Mohamed Parkar, Devina Bhowruth, Isabel Kingston, Caitriona O'Rourke, Agostino Virdis, Aroon Hingorani, Steven J. Hurel, Nikolaos Donos, Francesco D'Aiuto, John Deanfield International Journal of Cardiology Volume 271, Pages (November 2018) DOI: /j.ijcard Copyright © 2018 The Authors Terms and Conditions
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Fig. 1 Changes in mitochondrial reactive oxygen species production (mtROS) production during the study period in A) PBMC, B) Lymphocytes, C) Monocytes. I bars represent SE. mtROS production was significantly lower in PBMC (p < 0.01) and lymphocytes (p < 0.05) at 6 months in the IPT compared to the CPT group. International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions
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Fig. 2 A) Flow-mediated dilatation at baseline and 6 months after periodontal therapy. I bars represent SE. At 6 months of treatment, there was a significant difference in FMD between IPT and CPT groups (p < 0.03). B) Nitroglycerin-dependent dilation of the brachial artery in the IPT and CPT groups. I bars represent SE. At 6 months from treatment, no significant difference of the endothelial independent vasodilation was observed between IPT and CPT groups. International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions
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Fig. 3 Scatter plot reporting the significant association between changes of mitochondrial reactive oxygen species production (mtROS) in lymphocytes and changes in the flow mediated dilation (FMD) (r = 0.409; p = 0.042). International Journal of Cardiology , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions
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