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Combinatorial Enzymatic Synthesis of Heparan Sulfate
Robert J. Linhardt, Jin-Hwan Kim Chemistry & Biology Volume 14, Issue 9, Pages (September 2007) DOI: /j.chembiol Copyright © 2007 Elsevier Ltd Terms and Conditions
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Figure 1 Chemoenzymatic Synthetic Scheme of Polysaccharide Variants of Heparan Sulfate from E. coli Heparosan NDST is N-deacetylase N-sulfotransferase; OSTs are O-sulfotransferases; and Epi is C5 epimerase catalyzing the conversion of glucuronic acid to iduronic acid. PAPS is required as a sulfate donor for NDST and OST enzymes. Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2007 Elsevier Ltd Terms and Conditions
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Figure 2 Antithrombin Binding of Oligosaccharides and Full-Length Heparan Sulfate Polysaccharides as a Function of the Number of Saccharide Residues Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2007 Elsevier Ltd Terms and Conditions
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