1. SS-31 reduces inflammation after acute renal ischemia.
SS-31 reduces inflammation after acute renal ischemia. Rats were treated with SS-31 (2 mg/kg per day) or saline for 1.5 months starting 1 month after acute ischemia. (A) The number of CD68+ macrophages per glomerulus at various times after ischemia. The number shown reflects the average determined from ten glomeruli per sample and averaged. Data shown as mean±SEM; n=4/group; ***P< (B) Representative Western blot and densitometric analysis of TNF-α expression in renal cortical tissue at various times after acute ischemia. Data shown as mean±SEM; n=4/group; **P<0.01; ***P< (C) Representative Western blot and densitometric analysis of IL-18 expression in renal cortical tissue at various times after acute ischemia. Data shown as mean±SEM; n=4/group; **P<0.01; ***P< (D) Representative Western blot and densitometric analysis of IL-1β expression in renal cortical tissue at various times after acute ischemia in saline and SS-31-treated rats, versus age-matched controls. Data shown as mean±SEM; n=4/group; **P<0.01. (See Supplemental Figure 1 for all Western blots).
Hazel H. Szeto et al. JASN 2017;28:
©2017 by American Society of Nephrology