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Simvastatin suppresses experimental aortic aneurysm expansion

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1 Simvastatin suppresses experimental aortic aneurysm expansion
Arun Kalyanasundaram, MD, MPH, James R. Elmore, MD, James R. Manazer, MD, Alicia Golden, BS, David P. Franklin, MD, Spencer W. Galt, MD, Emad M.A. Zakhary, MD, David J. Carey, PhD  Journal of Vascular Surgery  Volume 43, Issue 1, Pages e39 (January 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Effects of simvastatin on aneurysm expansion. (Top) Aortic diameters for control rats and simvastatin-treated rats before elastase infusion, immediately after elastase infusion, and on postoperative day 7. Simvastatin significantly inhibited aneurysm expansion on postoperative day 7 as compared with controls (P = .0001). (Bottom) The percentage increase in aortic diameter was calculated as described in Methods and was significantly less in simvastatin-treated rats (P = .0012). Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Western blot analysis of matrix metalloproteinase (MMP)-9 and nuclear factor (NF)-κB. Lysates of aortas from control animals and simvastatin-treated animals were subjected to Western blot analysis with anti–MMP-9 and anti–NF-κB antibodies. The upper panels show representative Western blots. The bar graphs show means and standard errors. Expression levels for MMP-9 and NF-κB were decreased in simvastatin-treated tissue (P  < .05). Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 online only. Cluster analysis of genes with statistically significant differences in expression. Gene expression levels are reflected in the heat map colors. Red indicates increased expression; green indicates decreased expression. Each column represents a single aortic sample. All genes listed showed a significant difference in expression in simvastatin-treated animals (P < .05). Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 online only. Microarray data for genes related to oxidative stress. Gene expression levels are reflected in the heat map colors. Red indicates increased expression; green indicates decreased expression. Each column represents a single aortic sample. All genes listed showed a significant decrease in expression in simvastatin-treated animals (P < .05). Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 Microarray data for genes related to inflammation and immune function. Gene expression levels are reflected in the heat map colors. Red indicates increased expression; green indicates decreased expression. Each column represents a single aortic sample. All genes listed showed a significant decrease in expression in simvastatin-treated animals (P < .05). LPS, Lipopolysaccharide; TNF, tumor necrosis factor; Ig, immunoglobulin. Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

7 Fig 6 Microarray data for genes related to extracellular matrix (ECM) synthesis and remodeling. Gene expression levels are reflected in the heat map colors. Red indicates increased expression; green indicates decreased expression. Each column represents a single aortic sample. All genes listed showed a significant decrease in expression in simvastatin-treated animals (P < .05). Note that some genes are represented by multiple probes. Journal of Vascular Surgery  , e39DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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