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Clinical characteristics and genotype-phenotype correlations in C3 deficiency
Yuka Okura, MD, PhD, Ichiro Kobayashi, MD, PhD, Masafumi Yamada, MD, PhD, Satoshi Sasaki, MD, PhD, Yutaka Yamada, MD, Ichiro Kamioka, MD, PhD, Rie Kanai, MD, PhD, Yutaka Takahashi, MD, PhD, Tadashi Ariga, MD, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 2, Pages e1 (February 2016) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Severe infections preferentially develop in patients with C3 mutations in the N-terminal end of the TED domain. Domain arrangement of the C3 gene is shown. Both MG6 and CUB domains are formed by 2 separated parts, respectively. C3 mutations are indicated by asterisk marks. The mutations in Japanese and other ethnicities are shown in the lower and upper rows, respectively. The patient numbering follows that used in Table I. Journal of Allergy and Clinical Immunology , e1DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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