1. Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model 
D. Fries, A. Krismer, A. Klingler, W. Streif, G. Klima, V. Wenzel, T. Haas, P. Innerhofer 
British Journal of Anaesthesia 
Volume 95, Issue 2, Pages (August 2005)
DOI: /bja/aei160
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Thrombelastographic amplitude showing the dynamics of development of the clot (CT and CFT) and the clot firmness (MCF).
British Journal of Anaesthesia  , DOI: ( /bja/aei160)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
(a) ROTEM© analysis: CT, clotting time, (b) ROTEM© analysis: CFT, clot formation time, (c) ROTEM© analysis: MCF, maximal clot firmness and (d) ROTEM© analysis: alpha angle, at: baseline (1); after blood removal (2); after colloid administration (3); after substitution of fibrinogen or saline (4); as well as at the end of the observation period (5), in the animals treated with placebo (Gel) or fibrinogen concentrate (Fib). *Statistically significant differences between the fibrinogen group and the saline group with a P-value <0.05.
British Journal of Anaesthesia  , DOI: ( /bja/aei160)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Electron microscopy scan of a 2000× magnified blood clot in non-diluted state: dense, branched, and meshed reticular fibrin network.
British Journal of Anaesthesia  , DOI: ( /bja/aei160)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Electron microscopy scan of a 2000× magnified blood clot following approximately 65% haemodilution with gelatin: clearly rarified fibrin network.
British Journal of Anaesthesia  , DOI: ( /bja/aei160)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Electron microscopy scan of a 2000× magnified blood clot following administration of fibrinogen concentration to compensate for dilutional coagulopathy: in comparison with Figure 4 the fibrin network is again markedly compact. Because of the concomitant anaemia caused by 66% haemodilution, the clot shows only a few erythrocytes.
British Journal of Anaesthesia  , DOI: ( /bja/aei160)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions