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Glia Keep Synapse Distribution under Wraps

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Presentation on theme: "Glia Keep Synapse Distribution under Wraps"— Presentation transcript:

1 Glia Keep Synapse Distribution under Wraps
Laura E. Clarke, Ben A. Barres  Cell  Volume 154, Issue 2, Pages (July 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Glial Processes Maintain Presynaptic Site Distribution during Growth (A) In wild-type animals, an SLC17 transporter CIMA-1 negatively regulates EGL-15(5A) expression, by an unknown mechanism, to reduce epidermal-glia adhesion and prevent glial endfoot extension during growth. This interaction maintains the glial cell morphology, which in turn preserves the correct presynaptic site distribution during growth. (B) In animals with cima-1 loss-of-function mutations, or in animals in which egl-15(5A) is overexpressed, the interaction between the epidermal cells and the glia is misregulated. This results in the inappropriate extension of the glial endfeet, and the formation of ectopic presynaptic sites. Cell  , DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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