1. The Skinny on Fat Trm Cells
Stanley Cheuk, Liv Eidsmo 
Immunity 
Volume 47, Issue 6, Pages (December 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Adipose T Cells Provide Immunity at the Expense of Lipid Metabolism
(Left) WAT stores energy through active lipid metabolism but also hosts a wide range of immune cells, including T cells. Han et al. (2017) showed that WAT contains a substantial pool of Trm cells. Microbial infection prompted the generation of antigen-specific Trm cells. Adipose Trm cells displayed a distinct phenotype characterized by a high turnover rate and active metabolism, as measured by lipid uptake and mitochondrial respiration. Upon re-challenge, adipose Trm cells displayed potent effector function, inducing inflammatory and antimicrobial responses in adipose tissue. Intriguingly, reactivation of adipose Trm cells led to a sharp decrease in lipid synthesis, indicating a delicate balance between lipogenesis and antimicrobial responses within adipose tissue.
(Right) Both obesity and malnutrition are currently pressing global health issues. Malnutrition is often associated with a high burden of chronic infection, whereas obesity is associated with a number of chronic inflammatory diseases, such as psoriasis. It remains to be investigated whether the metabolic trade-off during the antimicrobial response mediated by adipose Trm cells might play a role in these processes.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions