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Type 2 Diabetes TCF7L2 Risk Genotypes Alter Birth Weight: A Study of 24,053 Individuals
Rachel M. Freathy, Michael N. Weedon, Amanda Bennett, Elina Hyppönen, Caroline L. Relton, Beatrice Knight, Beverley Shields, Kirstie S. Parnell, Christopher J. Groves, Susan M. Ring, Marcus E. Pembrey, Yoav Ben-Shlomo, David P. Strachan, Chris Power, Marjo-Riitta Jarvelin, Mark I. McCarthy, George Davey Smith, Andrew T. Hattersley, Timothy M. Frayling The American Journal of Human Genetics Volume 80, Issue 6, Pages (June 2007) DOI: /518517 Copyright © 2007 The American Society of Human Genetics Terms and Conditions
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Figure 1 Meta-analysis of the association of birth weight (corrected for sex and gestation) with fetal rs genotype across six studies, arranged in order of increasing size. The effect size (in grams) and 95% CI per risk allele is presented. Combined per-allele difference=18 g (95% CI 7–29 g); P=.001; I2=21.0%. The American Journal of Human Genetics , DOI: ( /518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions
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Figure 2 Meta-analysis of the association of birth weight (corrected for sex and gestation) with maternal rs genotype across three studies, arranged in order of increasing size. The effect size (in grams) and 95% CI per risk allele is presented. Combined per-allele difference=30 g (95% CI 15–45 g); P=2.8×10−5. I2=14.3%. The American Journal of Human Genetics , DOI: ( /518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions
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Figure 3 Bar graph showing sex- and gestational age–corrected birth-weight Z score plotted against the number of maternal risk alleles for TCF7L2 rs and GCK rs Error bars show 95% CIs. The American Journal of Human Genetics , DOI: ( /518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions
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