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Kelsie L. Thu, BSc, Raj Chari, PhD, William W

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1 miR-101 DNA Copy Loss is a Prominent Subtype Specific Event in Lung Cancer 
Kelsie L. Thu, BSc, Raj Chari, PhD, William W. Lockwood, PhD, Stephen Lam, MD, Wan L. Lam, PhD  Journal of Thoracic Oncology  Volume 6, Issue 9, Pages (September 2011) DOI: /JTO.0b013e d81 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 miR-101 genomic loss in lung cancer cell lines. A, miR-101 genomic losses at the 1p and 9p loci occur predominantly at one locus or the other. Of the 61 lung cancer cell lines with miR-101 genomic loss (indicated by gray boxes), 55 (90%) had deletions at only one miR-101 locus. B, DNA deletions of miR-101 are more frequent in non-small cell lung cancer (NSCLC) than in small cell lung cancer (SCLC) (Fisher's exact test, p = 8.3 × 10−6) and are more frequent in the adenocarcinoma subtype than in the squamous cell carcinoma subtype. C, Expression levels of miR-101 are higher in SCLC cell lines than in NSCLC cell lines (U test, p < ). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e d81) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Correlation of miR-101 genomic loss and expression in non-small cell lung cancer (NSCLC) tumors. miR-101 expression was assessed by quantitative polymerase chain reaction in 25 NSCLC tumor normal pairs. Expression of miR-101 is lowest in tumors with genomic loss and increases with increase in gene dosage. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e d81) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 miR-101 genomic loss in lung carcinoma in situ (CIS). miR-101 genomic losses were detected in lung CIS samples and deletions at the 1p and 9p loci were mutually exclusive in all but three cases (CIS3, CIS8, and CIS9). Regions for the lung CIS harboring miR-101 genomic loss are illustrated by horizontal lines, and genomic positions are shown relative to their chromosomal locations. CDKN2A status is also indicated. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e d81) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

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