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Published byLorin Merritt Modified over 6 years ago
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Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of risk for male infertility Amparo Mifsud, B.Sc., Chris K.S Sim, B.Sc., Holly Boettger-Tong, Ph.D., Sergio Moreira, M.D., Dolores J Lamb, Ph.D., Larry I Lipshultz, M.D., Eu Leong Yong, M.D. Fertility and Sterility Volume 75, Issue 2, Pages (February 2001) DOI: /S (00)
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Figure 1 (A), Polymorphic segments in exon 1 of the androgen receptor gene. The polymorphic CAG repeat tract (shaded box) and fragment containing codon 211 were amplified with flanking primers (arrows). Codons were numbered according to the method of Lubahn et al. (26). (B), Genescan analyses of androgen receptor CAG length. Electropherograms show alleles with 29 (A), 22 (B), and 14 (C) CAG repeats from azoospermic men, oligospermic men, and fertile controls, respectively. Polymerase chain reaction fragments (arrows) were internally labeled with a fluorescent marker (dCTP, R6G), and their length was measured by using red internal size standards (ROX, 500). Mifsud. Androgen receptor and male infertility. Fertil Steril 2001. Fertility and Sterility , DOI: ( /S (00) )
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Figure 2 Androgen receptor CAG allele distribution in normal fertile controls and azoospermic men. (A), Patients from Baylor College of Medicine, Houston, Texas. (B), Patients from National University Hospital, Singapore. Mifsud. Androgen receptor and male infertility. Fertil Steril 2001. Fertility and Sterility , DOI: ( /S (00) )
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