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Gut microbiome variations during hematopoietic stem cell transplant in severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher J. Stewart,

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Presentation on theme: "Gut microbiome variations during hematopoietic stem cell transplant in severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher J. Stewart,"— Presentation transcript:

1 Gut microbiome variations during hematopoietic stem cell transplant in severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher J. Stewart, PhD, Stephen P. Cummings, PhD, Andrew R. Gennery, MD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 6, Pages e2 (June 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 PLS-DA (partial least squares discriminant analysis) combining the gut microbiome profile of all 3 infants. Samples were designated as pre- or post-HSCT samples. The analysis shows that the samples can be grouped according to pre- and post-HSCT categories. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Changes in proportional bacterial profile of the gut microbiome in babies A, B, and D over the period of HSCT. Significant events are noted including chemotherapy, day of HSCT (day 0), antibiotic use, significant infections, and GvHD occurrence. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Changes in Shannon diversity index in babies A, B, and D over the period of HSCT. Significant events are noted including chemotherapy, day of HSCT (day 0), antibiotic use, significant infections, and GvHD occurrence. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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