1. Antithrombotic Therapy in PAD

2. Peripheral Artery Disease (PAD) Prevalence and Clinical Awareness

3. Risk Factors for PAD

4. Identifying Patients With PAD Importance of History and Performing Ankle-Brachial Index

5. Lower Extremity Amputation Geographic Variation in the United States

6. Comprehensive Approach to Management Needed

7. COMPASS Active and Nonactive Clinical Conditions at Baseline

8. Goals of Therapy

9. Patients With PAD in Denmark

10. US Analysis Also Found Underuse of Guideline-Recommended Therapies for PAD

11. Antiplatelet Therapy for PAD AHA/ACC Guidelines Class I, IIa

12. Anticoagulation in PAD WAVE

13. COMPASS 27,395 Subjects, 602 Sites, 33 Countries

14. COMPASS Population

15. COMPASS Primary Outcome CV Death, Stroke, MI

16. COMPASS Components of Primary Outcome

17. COMPASS Cumulative Incidence Risk of MACE

18. COMPASS: Composite Outcomes for PAD CV Death, Stroke, MI, MALE (Including Major Amputation)

19. COMPASS PAD Subgroup Major Adverse Limb Events (MALE) and Major Amputation

20. COMPASS Major Bleeding (PAD Subgroup)

21. Rivaroxaban FDA Approval

22. COMPASS Independent Predictors of MALE

23. Patient Considerations: Those at Highest Risk

24. VOYAGER PAD Ongoing

25. Recent Pathology Research Examines Below and Above Knee Amputations

26. Summary

27. Abbreviations

28. Abbreviations (cont)