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Efficacy and Safety of Ex Vivo Cultured Adult Human Mesenchymal Stem Cells (Prochymal™) in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host.

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Presentation on theme: "Efficacy and Safety of Ex Vivo Cultured Adult Human Mesenchymal Stem Cells (Prochymal™) in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host."— Presentation transcript:

1 Efficacy and Safety of Ex Vivo Cultured Adult Human Mesenchymal Stem Cells (Prochymal™) in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host Disease in a Compassionate Use Study  Vinod K. Prasad, Kenneth G. Lucas, Gary I. Kleiner, Julie An M. Talano, David Jacobsohn, Gloria Broadwater, Rod Monroy, Joanne Kurtzberg  Biology of Blood and Marrow Transplantation  Volume 17, Issue 4, Pages (April 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Responses in various organs at the end of Prochymal therapy.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Kaplan-Meier estimates of the probability of 2-year OS according to GVHD response following Prochymal therapy. Seven patients had a complete response to Prochymal, and whereas the remaining 5 patients (Non-CR) had partial or mixed response. Surviving patients have been followed for a median of 611 days (range, ). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

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