1. Volume 61, Issue 3, Pages 1056-1063 (March 2002)
Enhanced renal cortical vascularization in experimental hypercholesterolemia 
Michael D. Bentley, Martin Rodriguez-Porcel, Amir Lerman, Mirit Hershman Sarafov, J. Carlos Romero, Laura I. Pelaez, Joseph P. Grande, Erik L. Ritman, Lilach O. Lerman 
Kidney International 
Volume 61, Issue 3, Pages (March 2002)
DOI: /j x
Copyright © 2002 International Society of Nephrology Terms and Conditions

2. Figure 1
Micro-computed tomography three-dimensional (μCT) images of cortex and medulla in kidney lobes removed from control and high cholesterol pigs, showing a visually appreciable increase in spatial density of inner cortical microvessels in the latter. The displayed voxel size is 40 μm and the imaged tissue is 30 sections (1200 μm) thick.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

3. Figure 2
Sample cross-sections (40 μm thick) of inner, middle, and outer cortical tissue of control and high cholesterol kidneys, showing increased number of inner cortical microvessels in high cholesterol kidneys. The displayed voxel size is 40 μm, and the imaged area is 16mm2 (Scale bar is 500 μm).
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

4. Figure 3
Comparison of radial vessels rendered from μ-CT volume images of control and high cholesterol kidneys. In each kidney the vessels extend radially from the arcuate origin at the bottom of the images to the outermost cortex at the top. The vascular tree of the high cholesterol kidney shows a sizable increase in ramifications compared to the control kidney. The displayed voxel size is 40 μm (Scale bar is 500 μm).
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

5. Figure 4
Number of vessels ranging between 80 and 360 μm in diameter in the cortical zones of control (▪) and high cholesterol (•) kidneys. *Significant difference (P < 0.05) between control and high cholesterol groups.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

6. Figure 5
Size distribution pattern of microvessels in the (A) outer, (B) middle and (C) inner cortical regions of control () and high cholesterol (▪) kidneys.*Significant difference (P < 0.05) between control and high cholesterol groups.
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions

7. Figure 6
Light microscope sections of vascular endothelial growth factor (VEGF) immunohistochemistry in cortical tissue from control (A) and high cholesterol (B) kidneys. Note that VEGF immunostaining (arrows) in the thick ascending limbs and collecting ducts in the medullary rays and around the blood vessels is heavier in the high cholesterol kidney compared to the control kidney. (C) Focal mononuclear infiltration in a high cholesterol kidney. Positive immunostaining for VEGF is observed in many of the infiltrating cells (inset, ×4 enlargement).
Kidney International  , DOI: ( /j x)
Copyright © 2002 International Society of Nephrology Terms and Conditions