1. Oligopeptides bound with HLA-A2 or with HLA-A2 and C25 TCR
Oligopeptides bound with HLA-A2 or with HLA-A2 and C25 TCR. (A) Overlay of seven complex models that adopted a common main-chain groove conformation.
Oligopeptides bound with HLA-A2 or with HLA-A2 and C25 TCR. (A) Overlay of seven complex models that adopted a common main-chain groove conformation. (B) Overlay of three complex models that adopted a common main-chain oligopeptide conformation. (C) Overlay of two complex models showing different main-chain oligopeptide conformations and the contracted groove conformation of 597LAV relative to that of 597LAE. (D) Overlay of two complex models showing different main-chain oligopeptide conformations and the contracted groove conformation of 316VLM relative to that of 316VLE. (E) Overlay of six complex models showing five contracted groove conformations relative to that of 495NLV. (F) Overlay of the 495NLV·HLA-A2 model onto the crystal structure of 495NLV·HLA-A2·TCRC25 (PDB ID: 5D2N).
Yuan-Ping Pang et al. ImmunoHorizons 2018;2:
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