1. Number of patients who received at least one prescription for a COX-2 inhibitor or NSAID after hospital discharge
Drug
Patients
% of study cohort
Rofecoxib
3 022
5.2
Celecoxib
2 489
4.3
Diclofenac
6 172
10.6
Ibuprofen
10 230
17.5
Other NSAIDs
7 449
12.7
Gislason G. American Heart Association Scientific Sessions 2005; Nov 13-16, 2005; Dallas, TX.
COX-2 inhibitors/NSAIDs increase risk of death in patients with previous MI [Rheumawire > News; Nov 14, 2005

2. Hazard ratio for all-cause death in patients taking COX-2 inhibitors/NSAIDs vs those not taking such drugs
Drug/dosage
Hazard ratio for all-cause death
Rofecoxib >25 mg/day
5.03
Rofecoxib lower doses
2.23
Celecoxib >200 mg/day
4.24
Celecoxib lower doses
1.70
Diclofenac >100 mg/day
3.76
Diclofenac lower doses
0.7
Ibuprofen >1200 mg/day
1.96
Ibuprofen lower doses
0.66
Other NSAIDs (any dose)
1.22
Gislason G. American Heart Association Scientific Sessions 2005; Nov 13-16, 2005; Dallas, TX.
COX-2 inhibitors/NSAIDs increase risk of death in patients with previous MI [Rheumawire > News; Nov 14, 2005