1. Exploiting Old Pathogens to Create New Therapeutics
Tiffany Bouchery, Nicola L. Harris 
Cell Host & Microbe 
Volume 20, Issue 6, Pages (December 2016)
DOI: /j.chom
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Modulation of Allergic Airway Inflammation by the Parasitic Protein AIP-2
Intestinal-dwelling hookworms secrete an array of proteins, including AIP-2, which is taken up by migratory CD103+ dendritic cells (DCs). CD103+ DCs then migrate to the draining mesenteric lymph nodes where they promote the activation and expansion of regulatory T cells over allergy-promoting effector T cells. This process can also be mimicked by peritoneal inoculation of total parasite secreted products or recombinant AIP-2 into mice. The presence of an increased regulatory T cell pool in turn suppresses the development of allergic immune responses in the lung.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2016 Elsevier Inc. Terms and Conditions