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Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin  Khaled K. Al-Qattan, Martha.

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Presentation on theme: "Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin  Khaled K. Al-Qattan, Martha."— Presentation transcript:

1 Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin  Khaled K. Al-Qattan, Martha Thomson, Muslim Ali, Mohamed H. Mansour  Pathophysiology  Volume 20, Issue 2, Pages (April 2013) DOI: /j.pathophys Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Effect of garlic extract on serum insulin in diabetic rats. NS-NR, normal saline-treated normal rats; NS-DR, normal saline-treated diabetic rats; G-DR, garlic-treated diabetic rats. aSignificantly different compared to NS-NR; bsignificantly different compared to NS-DR. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Effect of garlic extract on serum glucose in diabetic rats. NS-NR, normal saline-treated normal rats; NS-DR, normal saline-treated diabetic rats; G-DR, garlic-treated diabetic rats. aSignificantly different compared to NS-NR; bsignificantly different compared to NS-DR; csignificantly different compared to week-1. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Effect of garlic extract on glycated hemoglobin in diabetic rats. NS-NR, normal saline-treated normal rats; NS-DR, normal saline-treated diabetic rats; G-DR, garlic-treated diabetic rats. aSignificantly different compared to NS-NR; bsignificantly different compared to NS-DR. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Effect of garlic extract on the glomerulus in diabetic rats. NS-NR/1, normal saline-treated normal rats’ renal cortex at 100× magnification; NS-NR/2, normal saline-treated normal rats’ renal corpuscle at 400× magnification; NS-DR/1, normal saline-treated diabetic rats’ renal cortex at 100× magnification; NS-DR/2, normal saline-treated diabetic rats’ renal corpuscle at 400× magnification; G-DR/1, garlic-treated diabetic rats’ renal cortex at 100× magnification; G-DR/2, garlic-treated diabetic rats’ renal corpuscle at 400× magnification; T-1, type 1; T-2, type 2; T-3, type 3; RC, renal corpuscle; Gs, glomerulus; CM, capsular membrane; CV, capillary vessel; MS, messengial substance; CS, capsular space; VP, vascular pole; PTP, proximal tubule pole. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Renal corpuscle (glomerulus) at different stages of damage in diabetic rats. NS-DR/a, normal saline-treated diabetic rats glomerulus at 400× magnification – early stage of damage; NS-DR/b, normal saline-treated diabetic rats’ glomerulus at 400× magnification – mid-stage of damage; NS-DR/c, normal saline-treated diabetic rats’ glomerulus at 400× magnification – late-stage of damage; Gs, glomerulus. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions

7 Fig. 6 Effect of garlic extract on percentage of glomerular type in diabetic rats. NS-NR, normal saline-treated normal rats; NS-DR, normal saline-treated diabetic rats; G-DR, garlic-treated diabetic rats; T-1, type-1 renal corpuscle (glomerulus); T-2, type-2 renal corpuscle (glomerulus); T-3 type-3 renal corpuscle (glomerulus). aSignificantly different in the same group; bsignificantly different compared to T-2 in NS-NR; csignificantly different compared to T-3 in C-DR. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2013 Elsevier Ireland Ltd Terms and Conditions


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