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Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions  Maria José Torres, MD, PhD,

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Presentation on theme: "Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions  Maria José Torres, MD, PhD,"— Presentation transcript:

1 Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions  Maria José Torres, MD, PhD, Adriana Ariza, PhD, Cristobalina Mayorga, PhD, Inmaculada Doña, MD, PhD, Natalia Blanca-Lopez, MD, PhD, Carmen Rondon, MD, PhD, Miguel Blanca, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 2, Pages e2 (February 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Skin test results using amoxicillin (20 mg/mL), amoxicillin-clavulanic acid (20/4 mg/mL), and clavulanic acid (20 mg/mL) in patient 55C. On the left are shown prick results (all negative) and on the right intradermal results (only positive to clavulanic acid). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Mean and SD of SI from BAT in positive cases in the 3 groups, with benzylpenicillin (BP), amoxicillin (AX), AX-CLV, and CLV at different concentrations (mg/mL). The AX-CLV concentration expresses the AX concentration in the combination. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 A, Wortmannin inhibitory effect in basophil activation under different conditions: positive controls (fMLP and anti-IgE), benzylpenicillin (BP), amoxicillin (AX), AX-CLV, and CLV at different concentrations (mg/mL). These data show the mean SI from 4 patients of group C. B, BAT results at different CLV concentrations (1.25, 0.5, 0.25, and 0.05 mg/mL) during a follow-up period of 12 months. These figures represent individual data from 4 patients of group C. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Dose -response curve for positive patients (N = 8) and controls (N = 8), responders to AX-CLV (A) or CLV (B). Results are expressed as the SIs (means ± SEMs). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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