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Stuart M. Levitz, Douglas T. Golenbock  Cell 

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Presentation on theme: "Stuart M. Levitz, Douglas T. Golenbock  Cell "— Presentation transcript:

1 Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research 
Stuart M. Levitz, Douglas T. Golenbock  Cell  Volume 148, Issue 6, Pages (March 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 PRRs Targeted by Vaccine Adjuvants
TLR1, TLR2, TLR4, TLR5, and TLR6 are located on the cell surface. TLR2 forms a heterodimer with TLR1 or TLR6. TLR3, TLR7, and TLR9 translocate from the endoplasmic reticulum to endolysosomal compartments following cell stimulation. The CLRs are cell surface receptors, whereas the NLRs and RLRs reside in cytoplasm. The interaction of a PRR with its cognate ligand results in initiation of a signaling cascade leading to inflammatory responses. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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