1. Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma 
Susan O'Brien, Peter Hillmen, Steven Coutre, Paul M. Barr, Graeme Fraser, Alessandra Tedeschi, Jan A. Burger, Marie-Sarah Dilhuydy, Georg Hess, Carol Moreno, Paula Cramer, Emily Liu, Stephen Chang, Jessica Vermeulen, Lori Styles, Angela Howes, Danelle F. James, Kalpesh Patel, Thorsten Graef, Rudolph Valentino 
Clinical Lymphoma, Myeloma and Leukemia 
Volume 18, Issue 10, Pages e15 (October 2018)
DOI: /j.clml
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2. Supplemental Figure 1
Prevalence of Most Common (≥ 10%) All-grade Adverse Events With Ibrutinib Over Time
Abbreviation: URTI = upper respiratory tract infection.
Clinical Lymphoma, Myeloma and Leukemia  , e15DOI: ( /j.clml )
Copyright © 2018 The Authors Terms and Conditions

3. Supplemental Figure 2
Prevalence of Most Common (≥ 3%) Grade 3/4 Adverse Events With Ibrutinib Over Time
Clinical Lymphoma, Myeloma and Leukemia  , e15DOI: ( /j.clml )
Copyright © 2018 The Authors Terms and Conditions

4. Supplemental Figure 3
(A) Mean Platelet, (B) Hemoglobin, and (C) Neutrophil Counts Over Time
Abbreviations: ANC = absolute neutrophil count; SEM = standard error of the mean.
Clinical Lymphoma, Myeloma and Leukemia  , e15DOI: ( /j.clml )
Copyright © 2018 The Authors Terms and Conditions

5. Supplemental Figure 4
Liver Values Over Time in Studies (A) 1112, (B) 1115, (C) CLL3001, and (D) MCL3001
Abbreviations: ALT = alanine transaminase; AST = aspartate transaminase; SEM = standard error of the mean.
Clinical Lymphoma, Myeloma and Leukemia  , e15DOI: ( /j.clml )
Copyright © 2018 The Authors Terms and Conditions

6. Supplemental Figure 4
Liver Values Over Time in Studies (A) 1112, (B) 1115, (C) CLL3001, and (D) MCL3001
Abbreviations: ALT = alanine transaminase; AST = aspartate transaminase; SEM = standard error of the mean.
Clinical Lymphoma, Myeloma and Leukemia  , e15DOI: ( /j.clml )
Copyright © 2018 The Authors Terms and Conditions