1. Fig. 1. MAHALO clinical trial flowchart.
MAHALO clinical trial flowchart. This was a phase 2, multicenter, randomized, controlled study that investigated the safety, tolerability, pharmacokinetics, and evidence of activity of lampalizumab in patients with geographic atrophy secondary to AMD. One hundred twenty-nine eligible patients were randomized 1:2:1:2 to sham monthly, 10-mg lampalizumab monthly, sham every other month, or 10-mg lampalizumab every other month. *One hundred twenty-three patients met the prespecified modified intention-to-treat (mITT) criteria for primary efficacy analysis. This population included all randomized patients who had one or more treatment injections and one or more post-baseline geographic atrophy measurements. Sham arms were pooled for analyses.
Brian L. Yaspan et al., Sci Transl Med 2017;9:eaaf1443
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