1. Formula feeding affects the resistome.
Formula feeding affects the resistome. (A) Class D beta-lactamase is enriched in formula-fed infants at 4 weeks of age (Mann-Whitney U = 66, Bonferroni-corrected P = 0.031). (B) Phylogenetic tree of Clostridium difficile genomes based on the ribosomal protein S3 gene. Names of genomes harboring a class D beta-lactamase are colored green and labeled with an asterisk. (C) The relative abundances of C. difficile genomes with class D beta-lactamase in formula-fed and breast-fed infants (top) (n = 38) and the relative abundances of C. difficile genomes lacking class-D betalactamase in formula-fed and breast-fed infants (bottom) (n = 29). Only the infants harboring C. difficile were included in calculations of average relative abundances.
Sumayah F. Rahman et al. mSystems 2018; doi: /mSystems