1. How organelles work together in cells
Learning outcomes:
Be able to demonstrate and apply your knowledge and understanding of…..
The interrelationship between the organelles involved in the production and secretion of proteins.

2. Starter
Cells and microscopes quick quiz.

3. Task – you are going to learn how organelles work together to make and secrete a hormone.
Use your notes from previous lessons to…….
Write down what sort of chemical a hormone is.
List the organelles that you think would be involved in this process.
Can you attempt to write down a bullet pointed process for making and secreting a protein. (This is tough!!!)

4. Making and secreting a protein
Making and secreting a protein. – Place the statements into the correct order…
Division of labour in cells can be well-demonstrated by the process of protein synthesis (where, in this case, a hormone is made):
The gene that has the coded instructions for a protein such as insulin, housed on chromatin in the nucleus, is transcribed into a length of RNA called messenger RNA (mRNA).
Many copies of this mRNA are made and they pass out of the pores in the nuclear envelope to the ribosomes.
At the ribosomes, the instructions are translated and insulin molecules are assembled.
The insulin molecules pass into the cisternae of the rER and along these hollow sacs.
Vesicles with insulin inside are pinched off from the rER and pass, via microtubules and motor proteins, to the Golgi apparatus.
The vesicles fuse with the Golgi apparatus, where the insulin protein molecules may be modified for release.
Inside vesicles pinched off from the Golgi apparatus, these molecules pass to the plasma membrane.
The vesicles and plasma membrane fuse, and the insulin is released to the outside of the cell.
This is a type of bulk transport called exocytosis, an active process for which energy is needed.

5. Plenary
Cells mini-test.

6. How organelles work together in cells
Learning outcomes:
Be able to demonstrate and apply your knowledge and understanding of…..
The interrelationship between the organelles involved in the production and secretion of proteins.