Presentation is loading. Please wait.

Presentation is loading. Please wait.

Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch  Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,

Published byLeon O’Neal’ Modified over 5 years ago

Similar presentations

Presentation on theme: "Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch  Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,"— Presentation transcript:

1 Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch 
Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi, MD, PhD, Tanveer A Khan, MD, Renato Faro, PhD, Jian-Ping Zhang, MD, William E Cohn, MD  The Annals of Thoracic Surgery  Volume 75, Issue 5, Pages (May 2003) DOI: /S (02) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Experimental model. In test animals, a submucosal gastric patch based on a gastroepiploic arteriovenous pedicle (GEA) was transferred through the diaphragm and apposed directly against the lateral myocardium, made ischemic by the placement of an ameroid constrictor (A) around the left circumflex artery (LCx). Control animals underwent circumflex ameroid placement and abrasion of the lateral epicardium, but did not receive a submucosal gastric patch. The Annals of Thoracic Surgery  , DOI: ( /S (02) ) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Relative indices of myocardial perfusion determined with isotope-labeled microspheres. The perfusion ratios of collateral-dependent (LCx) over normal (LAD) myocardial territories were equivalent in the two groups at rest (1.10 ± 0.49 versus 0.95 ± 0.23, test [white bars] versus control [black bars] animals; p = 0.54), but were higher in test animals versus controls during pacing (1.05 ± 0.29 versus 0.69 ± 0.09, test versus controls; *p = 0.02). The Annals of Thoracic Surgery  , DOI: ( /S (02) ) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Gastroepiploic (GEA) arteriogram of a test animal at seven weeks. Patch contour (P), circumflex artery occlusion at the ameroid constrictor (A) level and reconstitution (LCx) from the patch, and drainage of contrast through the coronary sinus (CS) were observed. The Annals of Thoracic Surgery  , DOI: ( /S (02) ) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Lectin-positive endothelial cells (arrows) in the left circumflex territory at 7 weeks. Increased endothelial cell density was observed in test (T) animals (left) versus controls (C) (right). The Annals of Thoracic Surgery  , DOI: ( /S (02) ) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Representative immunoblots of VEGFR-1 and VE-Cadherin expression in collateral-dependent myocardial territories at 7 weeks. Expression of the endothelial cell marker VE-Cadherin was significantly increased in test (T) animals versus controls (C). The Annals of Thoracic Surgery  , DOI: ( /S (02) ) Copyright © 2003 The Society of Thoracic Surgeons Terms and Conditions

Download ppt "Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch  Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,"

Similar presentations

Recurrent Angina Caused by Coronary Subclavian Steal Syndrome Confirmed by Positron Emission Tomography  Paulo Cury Rezende, MD, Leandro Menezes Alves.

Recurrent Angina Caused by Coronary Subclavian Steal Syndrome Confirmed by Positron Emission Tomography  Paulo Cury Rezende, MD, Leandro Menezes Alves.
Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up  Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,

Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up  Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,
Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor  Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda,

Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor  Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda,
A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: Evolving.

A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: Evolving.
A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.

A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.
Direct Reimplantation as an Alternative Approach for Treatment of Anomalous Aortic Origin of the Right Coronary Artery  Kenta Izumi, MD, Manuel Wilbring,

Direct Reimplantation as an Alternative Approach for Treatment of Anomalous Aortic Origin of the Right Coronary Artery  Kenta Izumi, MD, Manuel Wilbring,
Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress  Munir Boodhwani,

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress  Munir Boodhwani,
Hybrid Surgical Angiogenesis: Omentopexy Can Enhance Myocardial Angiogenesis Induced by Cell Therapy  Taro Kanamori, MD, Go Watanabe, MD, Tamotsu Yasuda,

Hybrid Surgical Angiogenesis: Omentopexy Can Enhance Myocardial Angiogenesis Induced by Cell Therapy  Taro Kanamori, MD, Go Watanabe, MD, Tamotsu Yasuda,
Coronary artery bypass grafting with the descending branch of thelateral femoral circumflex artery used as an arterial conduit: Is arteriographicevaluation.

Coronary artery bypass grafting with the descending branch of thelateral femoral circumflex artery used as an arterial conduit: Is arteriographicevaluation.
Facile Stabilization and Exposure Techniques in Off-Pump Coronary Bypass Surgery  Murat Kurtoglu, MD, Sanser Ates, MD, Tuba Demirozü, MD, İbrahim Duvan,

Facile Stabilization and Exposure Techniques in Off-Pump Coronary Bypass Surgery  Murat Kurtoglu, MD, Sanser Ates, MD, Tuba Demirozü, MD, İbrahim Duvan,
Coronary artery bypass grafting with gastroepiploic artery composite graft  Toru Sato, MD, Tadashi Isomura, MD, Hisayoshi Suma, MD, Taiko Horii, MD, Norio.

Coronary artery bypass grafting with gastroepiploic artery composite graft  Toru Sato, MD, Tadashi Isomura, MD, Hisayoshi Suma, MD, Taiko Horii, MD, Norio.
Single-Trunk Anomalous Origin of Both Coronary Arteries From Pulmonary Artery: Serendipitous Diagnosis and Successful Surgical Treatment  Changwei Zhang,

Single-Trunk Anomalous Origin of Both Coronary Arteries From Pulmonary Artery: Serendipitous Diagnosis and Successful Surgical Treatment  Changwei Zhang,
Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: The.

Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: The.
Complications and Risk Assessment of 25 Years in Pediatric Pacing

Complications and Risk Assessment of 25 Years in Pediatric Pacing
Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF  G.Chad Hughes, MD, Shankha S Biswas, MD, Bangliang.

Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF  G.Chad Hughes, MD, Shankha S Biswas, MD, Bangliang.
Coronary Artery Revascularization (CARE) Registry: An Observational Study of On- Pump and Off-Pump Coronary Artery Revascularization  George Palmer, MD,

Coronary Artery Revascularization (CARE) Registry: An Observational Study of On- Pump and Off-Pump Coronary Artery Revascularization  George Palmer, MD,
Shigetoshi Mieno, MD, Richard T

Shigetoshi Mieno, MD, Richard T
Endothelial Cell-Seeded Bovine Internal Mammary Artery for Complete Revascularization  Pascal M. Dohmen, MD, PhD, Davide Gabbieri, MD, Alexander Lembcke,

Endothelial Cell-Seeded Bovine Internal Mammary Artery for Complete Revascularization  Pascal M. Dohmen, MD, PhD, Davide Gabbieri, MD, Alexander Lembcke,
Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up  Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up  Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,
Muhammad S. Khan, MD, Matthew R

Muhammad S. Khan, MD, Matthew R

Similar presentations

Ads by Google