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Expression of human telomerase subunit genes in primary lung cancer and its clinical significance  Mitsuyuki Arinaga, MD, Shigeki Shimizu, MD, Kunihiko.

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Presentation on theme: "Expression of human telomerase subunit genes in primary lung cancer and its clinical significance  Mitsuyuki Arinaga, MD, Shigeki Shimizu, MD, Kunihiko."— Presentation transcript:

1 Expression of human telomerase subunit genes in primary lung cancer and its clinical significance 
Mitsuyuki Arinaga, MD, Shigeki Shimizu, MD, Kunihiko Gotoh, MD, Nobuhiro Haruki, MD, Takao Takahashi, MD, Takashi Takahashi, MD, Tetsuya Mitsudomi, MD  The Annals of Thoracic Surgery  Volume 70, Issue 2, Pages (August 2000) DOI: /S (00)

2 Fig 1 Results of reverse transcription-polymerase chain reaction analysis of telomerase subunits and the TRAP assay for paired lung cancer and adjacent non-neoplastic lung tissues. (AD = adenocarcinoma; CS = carcinosarcoma; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; hTERC = human telomerase RNA component; hTERT = human telomerase catalytic subunit; N = non-neoplastic adjacent lung tissue; SQ = squamous cell carcinoma; T = tumor tissue; TEP1 = telomerase-associated protein; TRAP = telomeric repeat amplification protocol.) The Annals of Thoracic Surgery  , DOI: ( /S (00) )

3 Fig 2 Survival curves for patients with lung cancer stratified by expression of human telomerase catalytic subunit (hTERT) (p = 0.64). The solid line is for patients with hTERT-positive tumors (n = 82) and the hatched line is for those with hTERT-negative tumors (n = 10). The Annals of Thoracic Surgery  , DOI: ( /S (00) )

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