1. mTORC1 signalling links cellular growth with autophagy
mTORC1 signalling links cellular growth with autophagy A range of physiological signals affects the activation status of mTORC1, including growth factor signalling, cellular energy levels via AMP-activated kinase (AMPK), oxygen levels and nutrients, particularly amino acids. The activation of mTORC1 regulates a number of cellular processes that affect the metabolic state of the cell. Through different mechanisms, mTORC1 signalling inhibits autophagy while promoting cell growth by stimulating biosynthetic pathways, including the synthesis of proteins, lipids and nucleotides.
Yoana Rabanal-Ruiz et al. Essays Biochem. 2017;61:
©2017 by Portland Press Ltd