1. Expert Perspectives in the Recognition and Management of Lennox-Gastaut Syndrome

3. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States.

4. Introduction to LGS

5. Epidemiology of LGS

6. Epidemiology of LGS (cont)

7. Symptom Presentation

8. Atonic-Clonic Seizure

9. Tonic Seizure

10. Tonic Seizure Symptomatic Generalized Epilepsy

11. LGS Triad

12. EEG Findings in LGS

13. Differential Diagnosis

14. Evaluation

15. EEG Characteristics

16. Treatment Goals

17. Treatment Options

18. Pharmacologic Treatment

19. FDA-Approved Pharmacologic Treatment for LGS*

20. Felbamate: Adjunctive Therapy

21. Lamotrigine: Adjunctive Therapy

22. Topiramate: Adjunctive Therapy

23. Rufinamide: Adjunctive Therapy

24. Clobazam: Adjunctive Therapy

25. Challenges in the Treatment of LGS

26. Ketogenic Diet

27. Corpus Callosotomy

28. Vagus Nerve Stimulation

29. Investigational Treatment: Perampanel

30. Investigational Treatment: Cannabidiol

31. Comorbidities in LGS

32. Transition to Care by an Adult Neurologist

33. Conclusions

34. Abbreviations