1. Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair 
Kim S. Midwood, Yong Mao, Henry C. Hsia, Leyla V. Valenick, Jean E. Schwarzbauer 
Journal of Investigative Dermatology Symposium Proceedings 
Volume 11, Issue 1, Pages (September 2006)
DOI: /sj.jidsymp
Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Modulation of cell interactions with fibronectin matrices. (a) Adhesion, spreading, and contraction mediated by α5β1 integrin and syndecan-4 are reduced with deposition of tenascin-C into a 3D fibrin–fibronectin matrix (left). By blocking syndecan-4 binding to fibronectin, tenascin-C downregulates signaling through FAK and Rho GTPase. Cells expressing α4β1 integrin show reduced adhesion and are unable to spread on or contract a 3D fibrin–fibronectin matrix when the fibronectin is intact (right). (b) Conditions that support cell adhesion, spreading, and matrix contraction include cells that express α5β1 and syndecan-4 interacting with a 3D fibrin–fibronectin matrix (left) or α4β1-expressing cells interacting with 3D fibrin-fragmented fibronectin matrix (right). Dashed arrows indicate multiple steps between receptors and cell activities.
Journal of Investigative Dermatology Symposium Proceedings  , 73-78DOI: ( /sj.jidsymp )
Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions