1. terminally differentiated less tumorigenic/metastatic
Nuclear potency
Loss of potency
Normal
differentiated
somatic cells
differentiation
cancer generation
iPSCs reprogramming
lineage-switch
reprogramming
iPS cell reprogramming
ESCs
Normal
development
ASCs
Factor-based
reprogramming
iPSCs or
iPCSCs
iPCS cell reprogramming
Oncogenic
reprogramming
Re-differentiation
Figure 3
(legend in manuscript)
trans-differentiation or lineage switch
Can enforced lineage reprogramming suppress features of the malignant program?
terminally differentiated
less tumorigenic/metastatic
Adult
tumors
Cancer cells “blocked” in an intermediate differentiated state