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Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

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Presentation on theme: "Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone"— Presentation transcript:

1 Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone
Gilles Divita  Chemistry & Biology  Volume 17, Issue 7, Pages (July 2010) DOI: /j.chembiol Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 Design and Potency of Bioactive Cell-Penetrating Peptides
Cell-penetrating peptide (CPP) can be linked to inhibitor and targeting motif (TM) or computer-based optimized using (QSAR) (1) to a single sequence containing bioactive cell-penetrating sequence (BCPP) that will improve cellular uptake (3), endosomal release (4), and biological response (6), and a targeting motif (TM) that will favor either cell targeting (2) or cellular trafficking (5). Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2010 Elsevier Ltd Terms and Conditions

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