1. Venous endothelial function in postmenopausal women who are receiving long-term estrogen and progestagen therapy 
Concepción Ceballos, Constantino Ribes, José A Amado, M.D., Josefina Pérez, M.D., Marı́a Teresa Garcı́a Unzueta, José R de Berrazueta, M.D. 
Fertility and Sterility 
Volume 74, Issue 2, Pages (August 2000)
DOI: /S (00)

2. Figure 1
(A), Effect of nitric oxide (NO)–dependent relaxation of the dorsal hand vein induced by bradykinin, given at 2 (Bk 2), 4 (Bk 4), and 8 (Bk 8) pmol/min in group A. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group A did not receive hormone replacement therapy (HRT); and 12 months, after women in group A had received HRT for 6 months. The NO dependent relaxation improved significantly (∗∗P=.002). (B), Effect of NO-dependent relaxation of the dorsal hand vein induced by bradykinin at the above doses in group B. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group B had received HRT; and at 12 months, after women in group B had discontinued HRT for 6 months. At 6 months, significant improvement in NO-dependent relaxation was seen (∗∗∗P<.0001), but at 12 months, this effect was lost.
Ceballos. Venous endothelial function in HRT. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )

3. Figure 1
(A), Effect of nitric oxide (NO)–dependent relaxation of the dorsal hand vein induced by bradykinin, given at 2 (Bk 2), 4 (Bk 4), and 8 (Bk 8) pmol/min in group A. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group A did not receive hormone replacement therapy (HRT); and 12 months, after women in group A had received HRT for 6 months. The NO dependent relaxation improved significantly (∗∗P=.002). (B), Effect of NO-dependent relaxation of the dorsal hand vein induced by bradykinin at the above doses in group B. Values were measured at baseline (“Basal”); at 6 months, during which postmenopausal women in group B had received HRT; and at 12 months, after women in group B had discontinued HRT for 6 months. At 6 months, significant improvement in NO-dependent relaxation was seen (∗∗∗P<.0001), but at 12 months, this effect was lost.
Ceballos. Venous endothelial function in HRT. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )

4. Figure 2
Comparative inhibition of NO-dependent relaxation of the dorsal hand vein by administration of NG-monomethyl l-arginine (l-NMMA) in postmenopausal women. Women in group A had not received hormone replacement therapy at 6 months, whereas women in group B had been receiving it from baseline to that time point. The maximum relaxation achieved with bradykinin (Bk) was suppressed by the effect of l-NMMA, the competitive inhibitor of the nitric oxide precursor l-arginine. This finding indicates that bradykinin promotes relaxation through the release of endothelial nitric oxide.
Ceballos. Venous endothelial function in HRT. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )

5. Figure 3
Exogenous nitric oxide–independent relaxation of the dorsal hand vein in postmenopausal women induced by sodium nitroprusside (SNP). The effect of sodium nitroprusside was similar in group A (women who did not receive hormone replacement therapy in the 6 months after the baseline visit) and group B (women who received hormone replacement therapy in the 6 months after the baseline visit).
Ceballos. Venous endothelial function in HRT. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )