1. Long-Term Safety and Efficacy of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules, a Novel Formulation Containing Morphine and Sequestered Naltrexone, in Patients with Chronic, Moderate to Severe Pain 
Lynn R. Webster, MD, Randall Brewer, MD, Chao Wang, PhD, Doreen Sekora, MPH, Franklin K. Johnson, MS, David Morris, PhD, Joseph Stauffer, DO, MBA 
Journal of Pain and Symptom Management 
Volume 40, Issue 5, Pages (November 2010)
DOI: /j.jpainsymman
Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1 Patient disposition.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

3. Fig. 2
Mean percent change from baseline in average, worst, least, and current pain over duration of study for (a) ITT and (b) completer populations. aIncludes 2 patients who did not complete the study but provided assessments at week 52 visit.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

4. Fig. 3
Mean (standard error of the mean) plasma morphine concentrations over duration of study (patients in PK substudy [n=93]).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions