1. Anaerobic threshold responder analysis
FIX-HF-5
Trial design: Patients with NYHA III or IV heart failure and narrow QRS were randomized to cardiac contractility modulation plus optimal medical therapy (n = 215) vs. optimal medical therapy alone (n = 213).
Results
(p = 0.093)
Anaerobic threshold responder analysis: 17.6% with treatment vs. 11.7% with control (p = 0.093)
Peak VO2 improved by 0.65 ml/kg/min with treatment (p = 0.024)
Quality of life improved by -9.7 points with treatment (p < )
17.6 %
11.7
Conclusions
Among patients with advanced heart failure, low ejection fraction, and narrow QRS, cardiac contractility modulation failed to improve the primary efficacy outcome, anaerobic threshold
Cardiac contractility modulation did improve peak VO2 and quality of life
Anaerobic threshold responder analysis
Cardiac contractility modulation
Control
Presented by Dr. William Abraham at ACC.09/i2, Orlando, FL